Article

Elucidation of an anaerobic pathway for metabolism of L-carnitine-derived γ-butyrobetaine to trimethylamine in human gut bacteria

2021-01-25

Abstract excerpt

<h4>ABSTRACT</h4> Trimethylamine (TMA) is an important gut microbial metabolite strongly associated with human disease. There are prominent gaps in our understanding of how TMA is produced from the essential dietary nutrient L-carnitine, particularly in the anoxic environment of the human gut where oxygen-dependent L-carnitine-metabolizing enzymes are likely inactive. Here, we elucidate the chemical and genetic b...

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Literature Corpus work: 9270bee5-b54d-52da-9800-12500fc8256e
DOI: 10.1101/2021.01.25.428109

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