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Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism.

mBio - 11 Mar 2026

Woo Amelia Y M, Sandoval-Espinola Walter J, Bollenbach Maud, Wong Alison, Sakanaka-Yokoyama Mariko, Zhang Qijun, Nieto Vincent, Rey Federico E, Balskus Emily P

Abstract excerpt

Anaerobic metabolism of dietary choline to trimethylamine (TMA) by the human gut microbiome is a disease-associated pathway. The host's impaired ability to oxidize TMA to trimethylamine-N-oxide (TMAO) results in trimethylaminuria (TMAU), while elevated serum TMAO levels have been positively correlated with cardiometabolic disease. Small molecule inhibition of gut bacterial choline metabolism attenuates the...

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Choline
Gastrointestinal Microbiome
High-Throughput Screening Assays
Methylamines
Mice

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PMID: 41728982
DOI: 10.1128/mbio.01172-25
PMCID: PMC12977544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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