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Article

Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2012

Craciun Smaranda, Balskus Emily P

Abstract excerpt

Choline and trimethylamine (TMA) are small molecules that play central roles in biological processes throughout all kingdoms of life. These ubiquitous metabolites are linked through a single biochemical transformation, the conversion of choline to TMA by anaerobic microorganisms. This metabolic activity, which contributes to methanogenesis and human disease, has been known for over a century but has eluded...

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Identifiers

PMID: 23151509
DOI: 10.1073/pnas.1215689109
PMCID: PMC3535645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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