Article

Intratumoral LAG-3 + cells infiltration determines poor prognosis in patients with castration-naïve prostate cancer

2022-02-24

Abstract excerpt

<h4>Background: </h4> As a transmembrane immune checkpoint protein, lymphocyte-activation gene 3 (LAG-3) is expressed on activated T cells and natural killer cells, could negatively regulate CD8 + T cells activation and reshaped the phenotype of CD4 + T cells to trigger an immunosuppressive function. Previous studies had demonstrated the prognostic value of LAG-3 in different cancers. However, its value in evaluat...

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Literature Corpus work: 1bbe5c53-f28b-5780-a73e-c1394913158e
DOI: 10.21203/rs.3.rs-1383643/v1

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