Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene of the month: lymphocyte-activation gene 3 (LAG-3)

28 Jun 2021

Abstract excerpt

Lymphocyte-activation gene 3 (LAG-3) is a coreceptor found on activated T-lymphocytes activated B-lymphocytes and natural killer (NK) cells. It is closely related to CD4 where it shares multiple common and divergent features. It contains specific binding sites with high affinity to major histocompatibility complex (MHC) Class II and functions as an inhibitor of T-cell signalling. Tumour-infiltrating lymphocytes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34183437
DOI: 10.1136/jclinpath-2021-207517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene of the month: lymphocyte-activation gene 3 (LAG-3)PMID 34183437Read ↗

Lymphocyte-activation gene 3 in cancer immunotherapy: function, prognostic biomarker and therapeutic potentialsSemantic proximity Read ↗

Understanding LAG-3 SignalingSemantic proximity Read ↗

LAG-3: from molecular functions to clinical applicationsSemantic proximity Read ↗

LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3Semantic proximity Read ↗

Pan-cancer and single-cell analysis reveal dual roles of lymphocyte activation gene-3 (LAG3) in cancer immunity and prognosis.Semantic proximity Read ↗

Integrative analysis identified the key role of LAG3 in T cell exhaustion in gliomaSemantic proximity Read ↗

Development and characterization of Novel Small Molecule Inhibitors Targeting LAG-3 ProteinSemantic proximity Read ↗

LAG ‐3 transcriptomic expression patterns across malignancies: Implications for precision immunotherapeuticsSemantic proximity Read ↗

Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcomaSemantic proximity Read ↗

The Role of YY1 in the Regulation of LAG-3 Expression in CD8 T Cells and Immune Evasion in Cancer: Therapeutic ImplicationsSemantic proximity Read ↗

Molecular and Clinical Characterization of LAG3 in Breast Cancer Through 2994 SamplesSemantic proximity Read ↗

Defining mechanisms of co-inhibitory receptor Lymphocyte Activation Gene-3 (LAG-3) in T cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.