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Pan-cancer and single-cell analysis reveal dual roles of lymphocyte activation gene-3 (LAG3) in cancer immunity and prognosis.

Scientific reports - 15 Oct 2024

Wang Yongfeng, Zhao Yanzong, Zhang Guangming, Lin Yifeng, Fan Chunling, Wei Hui, Chen Shude, Guan Ling, Liu Kan, Yu Shenhan, Fu Liangyin, Zhang Jing, Yuan Yuan, He Jin, Cai Hui

Abstract excerpt

Lymphocyte activating gene-3 (LAG3) is a distinctive T cell co-receptor that is expressed on the surface of lymphocytes. It plays a special inhibitory immune checkpoint role due to its unique domain and signaling pattern. Our aim is to explore the correlation between LAG3 in cancers and physiological processes related to a range of cancers, as well as build LAG3-related immunity and prognostic models. By...

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Antigens, CD
Biomarkers, Tumor
DNA Methylation
Gene Expression Regulation, Neoplastic
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Single-Cell Analysis

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Identifiers

PMID: 39406840
DOI: 10.1038/s41598-024-74808-4
PMCID: PMC11480387

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