Article

PD-1/LAG-3 Dysfunctionality Signatures in Human Cancers

2023-03-15

Abstract excerpt

<h4>ABSTRACT</h4> A significant number of cancer patients do not benefit from PD-L1/PD-1 blockade immunotherapies. PD-1 and LAG-3 co-upregulation in T-cells is one of the major mechanisms of resistance by establishing a highly dysfunctional state in T-cells. To identify shared features associated to PD- 1/LAG-3 dysfunctionality in human cancers and T-cells, multiomic expression profiles were obtained for all TCGA...

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Literature Corpus work: 041f8af8-6029-5682-9fd3-d5a8e23db6eb
DOI: 10.1101/2023.03.10.23287087

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