Article
The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology.
Biochimica et biophysica acta - 1 Oct 2015
Detta Nicola, Frisso Giulia, Salvatore Francesco
Abstract excerpt
The aim of this mini-review is to draw together the main concepts and findings that have emerged from recent studies of the cardiac channel protein Nav1.5. This complex protein is encoded by the SCN5A gene that, in its mutated form, is implicated in various diseases, particularly channelopathies, specifically at cardiac tissue level. Here we describe the structural, and functional aspects of Nav1.5 including...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.