Article
Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia.
Circulation - 6 May 2003
Clancy Colleen E, Tateyama Michihiro, Liu Huajun, Wehrens Xander H T, Kass Robert S
Abstract excerpt
BACKGROUND: Many long-QT syndrome (LQTS) mutations in the cardiac Na+ channel result in a gain of function due to a fraction of channels that fail to inactivate (burst), leading to sustained current (Isus) during depolarization. However, some Na+ channel mutations that are causally linked to cardiac arrhythmia do not result in an obvious gain of function as measured using standard patch-clamp techniques. An...
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