Article

A reference-free strategy for circulating tumor DNA detection from whole-genome sequencing data

2025-07-27

Abstract excerpt

Circulating tumor DNA (ctDNA) is emerging as a promising biomarker for postoperative monitoring of cancer patients. Precise estimation of circulating tumor fraction is crucial for evaluating treatment effects and timely detection of disease recurrence. All current ctDNA detection methods that utilize whole-genome sequencing (WGS) data rely on the reference genome alignment of sequencing reads and often apply separ...

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Identifiers and source

Literature Corpus work: 1ba5c417-ad79-549f-98cc-1ca85524114e
DOI: 10.1101/2025.07.23.666290

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