Article

IL-2 Modulates Th2 cell Responses to Glucocorticoid: A Cause of Persistent Type 2 Inflammation?

2018-07-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Inhaled glucocorticosteroids (GCs) are the main treatment for asthma as they reduce type 2 cytokine (IL-4, IL-5 and IL-13) expression and induce apoptosis. Asthma severity is associated with GC insensitivity, increased type 2 inflammation and circulating Th2 cells. Since IL-2 is a T cell survival factor, we assessed whether IL-2 levels associate with the proportion of Th2 ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b89cf6e-f740-51d4-b74c-3a26bb533313
DOI: 10.1101/365783

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

IL-2 Modulates Th2 cell Responses to Glucocorticoid: A Cause of Persistent Type 2 Inflammation?DOI 10.1101/365783Read

BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosisSemantic proximity Read

Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes.Semantic proximity Read

T-helper type 2-driven inflammation defines major subphenotypes of asthma.Semantic proximity Read

Enhanced circulating ILC2s accompany by upregulated MDSCs in patients with asthma.Semantic proximity Read

Contributing factors to the pathobiology of asthma. The Th1/Th2 paradigm.Semantic proximity Read

Type-2 CD8 <sup>+</sup> T lymphocytes responsive to PGD <sub>2</sub> and LTE <sub>4</sub> in severe eosinophilic asthmaSemantic proximity Read

Elevated levels of circulating CD4(+) CRTh2(+) T cells characterize severe asthma.Semantic proximity Read

Group 3 innate lymphoid cells secret neutrophil chemoattractants and are insensitive to glucocorticoid via aberrant GR phosphorylationSemantic proximity Read

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells.Semantic proximity Read

IL-17RB+ granulocytes are associated with airflow obstruction in asthma.Semantic proximity Read

IL-1 Family Members IL-18 and IL-33 Upregulate the Inflammatory Potential of Differentiated Human Th1 and Th2 CulturesSemantic proximity Read

Increased serum IL-17A and Th2 cytokine levels in patients with severe uncontrolled asthma.Semantic proximity Read