Article
IL-17RB+ granulocytes are associated with airflow obstruction in asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 Dec 2016
Li Lin, Lukacs Nicholas W, Schaller Matthew A, Petersen Bryan, Baptist Alan P
Abstract excerpt
BACKGROUND: Interleukin (IL)-25 (IL-17E) is a proinflammatory cytokine that plays an important role in the T-helper type 2 cell pathway. The effects of IL-25 are mediated by its specific receptor, IL-17RB. Previous studies have defined an IL-17RB+ granulocyte population known as type 2 myeloid (T2M) cells that express T-helper type 2 cell cytokines. The correlation of IL-17RB+ granulocytes, T2M cells, and asthma...
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