Article
T-helper type 2-driven inflammation defines major subphenotypes of asthma.
American journal of respiratory and critical care medicine - 1 Sept 2009
Woodruff Prescott G, Modrek Barmak, Choy David F, Jia Guiquan, Abbas Alexander R, Ellwanger Almut, Koth Laura L, Arron Joseph R, Fahy John V
Abstract excerpt
RATIONALE: T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is considered the central molecular mechanism underlying asthma, and Th2 cytokines are emerging therapeutic targets. However, clinical studies increasingly suggest that asthma is heterogeneous. OBJECTIVES: To determine whether this clinical heterogeneity reflects heterogeneity in underlying molecular mechanisms related to Th2...
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