Article
Elevated levels of circulating CD4(+) CRTh2(+) T cells characterize severe asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jun 2016
Palikhe N S, Laratta C, Nahirney D, Vethanayagam D, Bhutani M, Vliagoftis H, Cameron L
Abstract excerpt
BACKGROUND: Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) is a receptor for PGD2 and expressed by T cells, eosinophils, basophils, and ILC2 cells. CRTh2 expression by CD4(+) T cells identifies the Th2 subset, and these cells have been characterized as allergen-specific central memory Th2 cells. Recently, activation of the PGD2 -CRTh2 pathway in the lungs was associated with severe...
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