Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contributing factors to the pathobiology of asthma. The Th1/Th2 paradigm.

Clinics in chest medicine - 1 Jun 2000

Colavita A M, Reinach A J, Peters S P

Abstract excerpt

CD4+ "helper" T-lymphocytes in murine and human models have been divided into Th1 and Th2 subclasses, characterized by the profile of cytokines they secrete: INF-gamma (and perhaps IL-2 and TNF-beta) by Th1 cells, and IL-4 (and perhaps IL-5, IL-6, IL-10, and IL-13) by Th2 cells. Although a strict division into Th1 and Th2 phenotypes in humans (unlike murine systems) may not be possible, the asthmatic diathesis in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Asthma
Share to Cytokines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immune Tolerance

Share to Interleukins

Share to Phenotype

Share to Signal Transduction

Share to T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 10907587
DOI: 10.1016/s0272-5231(05)70265-3

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contributing factors to the pathobiology of asthma. The Th1/Th2 paradigm.PMID 10907587Read ↗

Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes.Semantic proximity Read ↗

Immunobiology of the critical asthma syndrome.Semantic proximity Read ↗

Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease.Semantic proximity Read ↗

Which biomarkers are effective for identifying Th2-driven inflammation in asthma?Semantic proximity Read ↗

Inflammation in Asthma: Mechanistic Insights and the Role of Biologics in Therapeutic FrontiersSemantic proximity Read ↗

The role of T lymphocytes in the pathogenesis of asthma.Semantic proximity Read ↗

Type 2 immunity‐driven diseases: Towards a multidisciplinary approachSemantic proximity Read ↗

New perspectives on the regulation of type II inflammation in asthmaSemantic proximity Read ↗

Molecular Mechanisms RegulatinG Th1 Immune ResponsesSemantic proximity Read ↗

CD8+ T cells in asthma: friend or foe?Semantic proximity Read ↗

TH17 cells in asthma and inflammationSemantic proximity Read ↗

The Mechanisms of Effector Th Cell Responses Contribute to Treg Cell Function: New Insights into Pathogenesis and Therapy of AsthmaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.