BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis

doi:10.1111/all.12840

Article

BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis

11 Jan 2016

Abstract excerpt

BACKGROUND: Glucocorticoid resistance has been associated with Th17-driven inflammation, the mechanisms of which are not clear. We determined whether human and mouse Th17 cells are resistant to glucocorticoid-induced apoptosis. METHODS: Freshly isolated human blood Th17 cells and in vitro differentiated Th17 cells from IL-17F red fluorescent protein reporter mice were treated with dexamethasone, a potent...

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