Article

Type-2 CD8 <sup>+</sup> T lymphocytes responsive to PGD <sub>2</sub> and LTE <sub>4</sub> in severe eosinophilic asthma

2018-01-12

Abstract excerpt

<h4>ABSTRACT</h4> The functions and in vivo roles of type-2 CD8 + T cells in humans have not been well defined and this cell type has been largely overlooked in models of disease. We investigated this in the context of severe asthma with persistent airway eosinophilia - a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies. In two independent cohorts we show...

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Literature Corpus work: f42a237c-3986-5f92-af01-c70de76bd028
DOI: 10.1101/247171

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