Article
An ultra-deep sequencing strategy to detect sub-clonal TP53 mutations in presentation chronic lymphocytic leukaemia cases using multiple polymerases.
Oncogene - 6 Oct 2016
Worrillow L, Baskaran P, Care M A, Varghese A, Munir T, Evans P A, O'Connor S J, Rawstron A, Hazelwood L, Tooze R M, Hillmen P, Newton D J
Abstract excerpt
Chronic lymphocytic leukaemia (CLL) is the most common clonal B-cell disorder characterized by clonal diversity, a relapsing and remitting course, and in its aggressive forms remains largely incurable. Current front-line regimes include agents such as fludarabine, which act primarily via the DNA damage response pathway. Key to this is the transcription factor p53. Mutations in the TP53 gene, altering p53...
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