Article

The diagnostic chronic lymphocytic leukaemia genome by nanopore sequencing

2019-08-28

Abstract excerpt

Chronic lymphocytic leukaemia (CLL) is characterised by considerable clinical and biological heterogeneity, with specific recurrent genomic alterations, including TP53 mutations, deletions of chromosome 17p, and IgHV mutational status, impacting on response to chemo-immunotherapy and targeted agents. Consequently, diagnostic screening for these predictive biomarkers is recommended in both national and internation...

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Literature Corpus work: ed776933-68e5-5f89-981c-f136e38071b2
DOI: 10.1101/750059

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