Article

Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancer

2023-09-14

Abstract excerpt

<title>Abstract</title> <p>Chemo-immunotherapy combinations have been regarded as one of the most practical ways to improve immunotherapy response in cancer patients. In this study, we integrated the transcriptomics data from immunotherapy-treated tumors and compound-treated cell lines to systematically identify chemo-immunotherapy synergisms and their underlying mechanisms. Through analyzing anti-PD-1 treatment...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b7832e9-2df8-5cb2-b790-3c259c5c101c
DOI: 10.21203/rs.3.rs-3290264/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancerDOI 10.21203/rs.3.rs-3290264/v1Read

Holistic Understanding of the Current Landscape, Challenges, and Potential Advancements in the Integration of Immunotherapy with Traditional Cancer Treatments: A Narrative ReviewSemantic proximity Read

Deciphering molecular mechanisms of synergistic growth reduction in kinase inhibitor combinationsSemantic proximity Read

Landscape of Combination Immunotherapy and Targeted Therapy to Improve Cancer ManagementSemantic proximity Read

A statistical framework for defining synergistic anticancer drug interactionsSemantic proximity Read

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenograftsSemantic proximity Read

Personalized tumor combination therapy optimization using the single-cell transcriptomeSemantic proximity Read

Pisces: A multi-modal data augmentation approach for drug combination synergy predictionSemantic proximity Read

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenograftsSemantic proximity Read

The Landscape of Receptor-Mediated Precision Cancer Combination Therapy: A Single-Cell PerspectiveSemantic proximity Read

Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clonesSemantic proximity Read

Defining principles of combination drug mechanisms of action.Semantic proximity Read

Cancer immunotherapeutic challenges from autophagy-immune checkpoint reciprocal regulationSemantic proximity Read