Article

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts

2022-04-01

Abstract excerpt

Anticancer combination therapy has been developed to increase efficacy by enhancing synergy. Patient-derived xenografts (PDXs) have emerged as reliable preclinical models to develop effective treatments in translational cancer research. However, most PDX combination study designs focus on single dose levels, and dose-response surface models are not appropriate for testing synergism. We propose a comprehensive stat...

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Literature Corpus work: 5b830da8-8c94-5e53-832b-5fe312b2953e
DOI: 10.21203/rs.3.rs-1464274/v1

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