Article

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts

2021-10-20

Abstract excerpt

<h4>Motivation</h4> Anticancer combination therapy has been developed to increase efficacy by enhancing synergy. Patient-derived xenografts (PDXs) have emerged as reliable preclinical models to develop effective treatments in translational cancer research. However, in most PDX combination experiments, PDXs are tested on single dose levels and dose-response surface methods are not applicable for testing synergism....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bbef240b-c8e9-5c56-a142-3729665472a8
DOI: 10.1101/2021.10.19.464994

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenograftsDOI 10.1101/2021.10.19.464994Read

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenograftsSemantic proximity Read

A statistical framework for defining synergistic anticancer drug interactionsSemantic proximity Read

Pisces: A multi-modal data augmentation approach for drug combination synergy predictionSemantic proximity Read

Explainable machine learning prediction of synergistic drug combinations for precision cancer medicineSemantic proximity Read

SYNERGxDB: an integrative pharmacogenomic portal to identify synergistic drug combinations for precision oncology.Semantic proximity Read

Computational Advancements in Cancer Combination Therapy PredictionSemantic proximity Read

Correlated Drug Action as a Baseline Model for Combination Therapy in Patient Cohorts and Cell CulturesSemantic proximity Read

Predicting drug combination response surfacesSemantic proximity Read

MULTISCALE ANALYSIS AND VALIDATION OF EFFECTIVE DRUG COMBINATIONS TARGETING DRIVER KRAS MUTATIONS IN NON-SMALL CELL LUNG CANCERSemantic proximity Read

Methods for High-Throughput Drug Combination Screening and Synergy ScoringSemantic proximity Read

Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancerSemantic proximity Read

Multiscale Analysis and Validation of Effective Drug Combinations Targeting Driver KRAS Mutations in Non-Small Cell Lung Cancer.Semantic proximity Read