Article
Defining principles of combination drug mechanisms of action.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2013
Pritchard Justin R, Bruno Peter M, Gilbert Luke A, Capron Kelsey L, Lauffenburger Douglas A, Hemann Michael T
Abstract excerpt
Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many patients. Although their single-drug components are well studied, the mechanisms by which drugs work together in clinical combination regimens are poorly understood. Here, we combine RNAi-based functional signatures with complementary informatics tools to...
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