Article

Deciphering molecular mechanisms of synergistic growth reduction in kinase inhibitor combinations

2024-03-14

Abstract excerpt

In cancer treatment, the persistent challenge of unresponsiveness of certain patients to drugs or the development of resistance post-treatment remains a significant concern. Drug combinations that synergistically reduce tumor growth emerge as a promising avenue to address this issue. Here, we aimed to characterize the mechanism of action of two synergistic drug combinations that target PI3K together with MEK1 or w...

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Literature Corpus work: b3019b32-f0fc-5669-bdd9-cf3ae00b2d45
DOI: 10.1101/2024.03.12.584561

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