Article

The Evolution of Fluoroquinolone-Resistance in <i>Mycobacterium tuberculosis</i> is Modulated by the Genetic Background

2019-06-03

Abstract excerpt

Fluoroquinolones (FQ) form the backbone in experimental treatment regimens against drug-susceptible tuberculosis. However, little is known on whether the genetic variation present in natural populations of Mycobacterium tuberculosis ( Mtb ) affects the evolution of FQ-resistance (FQ-R). To investigate this question, we used a set of Mtb strains that included nine genetically distinct drug-susceptible clinical i...

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Literature Corpus work: 1b48d169-2d2e-56e9-9889-56672a7474c2
DOI: 10.1101/659045

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