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Article

Genomic Analysis of the Evolution of Fluoroquinolone Resistance in Mycobacterium tuberculosis Prior to Tuberculosis Diagnosis.

Antimicrobial agents and chemotherapy - 1 Nov 2016

Zhang Danfeng, Gomez James E, Chien Jung-Yien, Haseley Nathan, Desjardins Christopher A, Earl Ashlee M, Hsueh Po-Ren, Hung Deborah T

Abstract excerpt

Fluoroquinolones (FQs) are effective second-line drugs for treating antibiotic-resistant tuberculosis (TB) and are being considered for use as first-line agents. Because FQs are used to treat a range of infections, in a setting of undiagnosed TB, there is potential to select for drug-resistant Mycobacterium tuberculosis mutants during FQ-based treatment of other infections, including pneumonia. Here we present a...

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Identifiers

PMID: 27572408
DOI: 10.1128/AAC.00664-16
PMCID: PMC5075065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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