Article
Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity.
PLoS pathogens - 1 Dec 2016
Copin Richard, Wang Xueying, Louie Eddie, Escuyer Vincent, Coscolla Mireia, Gagneux Sebastien, Palmer Guy H, Ernst Joel D
Abstract excerpt
Molecular epidemiological assessments, drug treatment optimization, and development of immunological interventions all depend on understanding pathogen adaptation and genetic variation, which differ for specific pathogens. Mycobacterium tuberculosis is an exceptionally successful human pathogen, yet beyond knowledge that this bacterium has low overall genomic variation but acquires drug resistance mutations,...
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