Article
Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis.
PLoS pathogens - 1 Jun 2006
Gagneux Sebastian, Burgos Marcos V, DeRiemer Kathryn, Encisco Antonio, Muñoz Samira, Hopewell Phillip C, Small Peter M, Pym Alexander S
Abstract excerpt
Understanding the ecology of drug-resistant pathogens is essential for devising rational programs to preserve the effective lifespan of antimicrobial agents and to abrogate epidemics of drug-resistant organisms. Mathematical models predict that strain fitness is an important determinant of multidrug-resistant Mycobacterium tuberculosis transmission, but the effects of strain diversity have been largely...
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