Article

Host evolution improves genetic circuit function in complex growth environments

2024-03-13

Abstract excerpt

Genetically engineered bacteria have become an attractive platform for numerous biomedical and industrial applications. Despite genetic circuitry functioning predictably under favorable growth conditions in the lab, the same cannot be said when placed in more complex environments for eventual deployment. Here, we used a combination of evolutionary and rational engineering approaches to enhance E. coli for robust...

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Literature Corpus work: 1b4166b2-347e-5392-bfb5-38b271b7d28f
DOI: 10.1101/2024.03.13.583595

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