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Engineered Hypermutation Adapts Escherichia coli to Octanoic Acid Stress.

ACS synthetic biology - 19 Dec 2025

Zhang Minhao, Yu Chen, Zhang Jiaxiang, Fang Lixia, Cao Yingxiu

Abstract excerpt

Medium-chain fatty acids (MCFAs) are valuable biochemicals, yet their inherent toxicity limits microbial productivity. Here, we developed a tunable hypermutation system in Escherichia coli by modulating translesion synthesis (TLS) pathways to accelerate adaptive laboratory evolution (ALE) for enhanced octanoic acid (C8) tolerance. Overexpression of dinB, encoding error-prone DNA polymerase IV, under T7 and BAD...

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PMID: 41358936
DOI: 10.1021/acssynbio.5c00507

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BAD

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