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Evolution of Escherichia coli to 42 °C and subsequent genetic engineering reveals adaptive mechanisms and novel mutations.

Molecular biology and evolution - 1 Oct 2014

Sandberg Troy E, Pedersen Margit, LaCroix Ryan A, Ebrahim Ali, Bonde Mads, Herrgard Markus J, Palsson Bernhard O, Sommer Morten, Feist Adam M

Abstract excerpt

Adaptive laboratory evolution (ALE) has emerged as a valuable method by which to investigate microbial adaptation to a desired environment. Here, we performed ALE to 42 °C of ten parallel populations of Escherichia coli K-12 MG1655 grown in glucose minimal media. Tightly controlled experimental conditions allowed selection based on exponential-phase growth rate, yielding strains that uniformly converged toward a...

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Identifiers

PMID: 25015645
DOI: 10.1093/molbev/msu209
PMCID: PMC4166923

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Source receipt: pubmed, retrieved 7 Sept 2026.

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