Article

In-vivo fast non-linear microscopy reveals impairment of fast axonal transport induced by molecular motor imbalances in the brain of zebrafish larvae

2022-07-10

Abstract excerpt

Cargo transport by molecular motors along microtubules is essential for the function of eucaryotic cells, in particular neurons in which axonal transport defects constitute the early pathological features of neurodegenerative diseases. Mainly studied in motor and sensory neurons, axonal transport is still difficult to characterize in neurons of the brain in absence of appropriate in vivo tools. Here, we measured...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 198e7da5-7ad2-5ae0-810e-66cef1f3b3d9
DOI: 10.1101/2022.07.09.499436

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In-vivo fast non-linear microscopy reveals impairment of fast axonal transport induced by molecular motor imbalances in the brain of zebrafish larvaeDOI 10.1101/2022.07.09.499436Read

Zebrafish Tg(hb9:MTS-Kaede): a new in vivo tool for studying the axonal movement of mitochondria.Semantic proximity Read

The sets of kinesins and dynein transporting endocytic cargoes determine the effect of tau on their motilitySemantic proximity Read

Single-particle fluorescence tracking combined with TrackMate assay reveals highly heterogeneous and discontinuous lysosomal transport in freely orientated axonsSemantic proximity Read

In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system.Semantic proximity Read

A new method for quantifying mitochondrial axonal transport.Semantic proximity Read

DYRK1A role in microtubule-based axonal transport regulates the retrograde dynamics of APP vesicles in human neuronsSemantic proximity Read

Direct visualization of the movement of the monomeric axonal transport motor UNC-104 along neuronal processes in living Caenorhabditis elegans.Semantic proximity Read

Cargo crowding at actin‐rich regions along axons causes local traffic jamsSemantic proximity Read

Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides.Semantic proximity Read

Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3.Semantic proximity Read

Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons.Semantic proximity Read

A high-resolution phenotypic screen identifies regulators of CNS axon diameter in zebrafish.Semantic proximity Read