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Article

<i>C9orf72</i> -derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

2019-11-08

Abstract excerpt

<h4>ABSTRACT</h4> Hexanucleotide repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this mutation leads to these neurodegenerative diseases remains unclear. Here, we use human induced pluripotent stem cell-derived motor neurons to show that C9orf72 repeat expansions impair microtubule-based transport of mitochondr...

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Literature Corpus work
5e1fd998-031e-5b86-8318-b8ab3e9bc5bc
DOI
10.1101/835082
Open publication

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<i>C9orf72</i> -derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motilityDOI 10.1101/835082
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