Article
This paper is a winner in the Undergraduate category for the SFB awards: Evaluation of the tissue response to alginate encapsulated islets in an omentum pouch model.
Journal of biomedical materials research. Part A - 1 Jul 2016
Ibarra Veronica, Appel Alyssa A, Anastasio Mark A, Opara Emmanuel C, Brey Eric M
Abstract excerpt
Islet transplantation is currently in clinical use as a treatment for type I diabetes, but donor shortages and long-term immunosuppression limit broad application. Alginate microcapsules coated with poly-l-ornithine can be used to encapsulate islets in an environment that allows diffusion of glucose, insulin, nutrients, and waste products while inhibiting cells and antibodies. While clinical trials are ongoing...
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