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Article

Blood transcriptomic signature in type-2 biomarker-low severe asthma and asthma control

12 Jun 2023

Abstract excerpt

BACKGROUND: Patients with type-2 (T2) cytokine-low severe asthma often have persistent symptoms despite suppression of T2 inflammation with corticosteroids. OBJECTIVES: We sought to analyze whole blood transcriptome from 738 samples in T2-biomarker-high/-low patients with severe asthma to relate transcriptomic signatures to T2 biomarkers and asthma symptom scores. METHODS: Bulk RNA-seq data were generated for...

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PMID: 37315813
DOI: 10.1016/j.jaci.2023.05.023

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