Article

Bronchial gene expression clustering in COPD identifies a subgroup of patients with higher level of bronchial T-cells and accelerated lung function decline

2025-07-21

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with varying degrees of airway wall thickening, chronic bronchitis, and emphysema. A better understanding of the underlying pathology is needed to improve the personalized treatment of the disease and identify new therapeutic targets. Available data from 56 COPD patients included in the GLUCOLD study were used (61.1±7.7 years, 89% male, and FE...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac112d55-fbd5-5f24-a6c8-01bbf2a713fe
DOI: 10.1101/2025.07.21.25331922

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bronchial gene expression clustering in COPD identifies a subgroup of patients with higher level of bronchial T-cells and accelerated lung function declineDOI 10.1101/2025.07.21.25331922Read

Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes.Semantic proximity Read

Novel Type 2-high gene clusters associated with corticosteroid sensitivity in COPDSemantic proximity Read

Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study.Semantic proximity Read

The Chronic Bronchitic Phenotype of COPD: An Analysis of the COPDGene StudySemantic proximity Read

Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPDSemantic proximity Read

Gene Expression Profiles Reveal Distinct Mechanisms Driving Chronic Obstructive Pulmonary Disease ExacerbationsSemantic proximity Read

Clustering-based COPD Subtypes Have Distinct Longitudinal Outcomes and Multi-omics BiomarkersSemantic proximity Read

Distinct physiological, transcriptomic, and imaging characteristics of asthma-COPD overlap compared to asthma and COPD in smokers.Semantic proximity Read

Translating the COPD Transcriptome: Insights into Pathogenesis and Tools for Clinical ManagementSemantic proximity Read

Meta-analysis of Gene Expression Microarray Datasets in Chronic Obstructive Pulmonary DiseaseSemantic proximity Read

Novel computational analysis of large transcriptome datasets identifies sets of genes distinguishing chronic obstructive pulmonary disease from healthy lung samplesSemantic proximity Read

COPD phenotypes and machine learning cluster analysis: A systematic review and future research agenda.Semantic proximity Read