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Article

Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD

7 Dec 2022

Abstract excerpt

RATIONALE: Severe asthma and chronic obstructive pulmonary disease (COPD) share common pathophysiological traits such as relative corticosteroid insensitivity. We recently published three transcriptome-associated clusters (TACs) using hierarchical analysis of the sputum transcriptome in asthmatics from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort comprising one...

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PMID: 36598042
DOI: 10.1136/thorax-2021-217736

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