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Article

Airway gene expression identifies subtypes of type 2 inflammation in severe asthma

18 Jun 2021

Abstract excerpt

BACKGROUND: Type 2 inflammation is characterized by enhanced activity of interleukin (IL)-4, -5 and -13, and treatments targeting these pathways are available for treatment of severe asthma. At present, the pattern of pathway activity and the implications overlapping of pathway activity are unknown. OBJECTIVE: We hypothesized that clustering of airway mRNA expression would identify distinct molecular subtypes of...

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PMID: 34142396
DOI: 10.1111/cea.13966

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