Article

High-Grade Gliomas and Cancer Predisposition Syndromes in children and adolescents: Unpacking the Impact through a Single-Center Analysis

2023-08-10

Abstract excerpt

The correlation of pediatric high-grade gliomas with cancer predisposition syndromes (CPS) is poorly defined in the literature and next generation sequencing (NGS) is increasingly being used in support of diagnosis. We retrospectively analyzed NGS data from 77 consecutive children diagnosed with different types of pediatric high-grade glial tumors to identify the presence of germline variants predisposing to cance...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ae0cc12-abdd-5926-8514-9f1548f22078
DOI: 10.21203/rs.3.rs-3149437/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-Grade Gliomas and Cancer Predisposition Syndromes in children and adolescents: Unpacking the Impact through a Single-Center AnalysisDOI 10.21203/rs.3.rs-3149437/v1Read

Cancer Predisposition Syndromes Associated With Pediatric High-Grade GliomasSemantic proximity Read

Pediatric High Grade Gliomas in the Context of Cancer Predisposition SyndromesSemantic proximity Read

Germline genetic landscape of pediatric central nervous system tumors.Semantic proximity Read

Germline Predisposition in Pediatric Central Nervous System Tumors: Insights from a Multigene Panel Study.Semantic proximity Read

Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors—a nationwide, prospective Swedish studySemantic proximity Read

Genetic predisposition to central nervous system tumors in children - what the neurosurgeon should know.Semantic proximity Read

Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric CNS tumorsSemantic proximity Read

Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors.Semantic proximity Read

Genetic predisposition and evolutionary traces of pediatric cancer risk: a prospective 5-year population-based genome sequencing study of children with CNS tumors.Semantic proximity Read

Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.Semantic proximity Read

Gliomas in children and adolescents: investigation of molecular alterations with a potential prognostic and therapeutic impact.Semantic proximity Read

Integrated genetic profiling of archival pediatric high-grade glial tumors and reassessment with 2021 WHO classification of paediatric CNS tumours.Semantic proximity Read