Genetic predisposition and evolutionary traces of pediatric cancer risk: a prospective 5-year population-based genome sequencing study of children with CNS tumors.

doi:10.1093/neuonc/noac187

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Genetic predisposition and evolutionary traces of pediatric cancer risk: a prospective 5-year population-based genome sequencing study of children with CNS tumors.

Neuro-oncology - 6 Apr 2023

Stoltze Ulrik Kristoffer, Foss-Skiftesvik Jon, van Overeem Hansen Thomas, Byrjalsen Anna, Sehested Astrid, Scheie David, Stamm Mikkelsen Torben, Rasmussen Simon, Bak Mads, Okkels Henrik, Thude Callesen Michael, Skjøth-Rasmussen Jane, Gerdes Anne-Marie, Schmiegelow Kjeld, Mathiasen René, Wadt Karin

Abstract excerpt

BACKGROUND: The etiology of central nervous system (CNS) tumors in children is largely unknown and population-based studies of genetic predisposition are lacking. METHODS: In this prospective, population-based study, we performed germline whole-genome sequencing in 128 children with CNS tumors, supplemented by a systematic pedigree analysis covering 3543 close relatives. RESULTS: Thirteen children (10%) harbored...

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PMID: 35902210
DOI: 10.1093/neuonc/noac187
PMCID: PMC10076945

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