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Article

Germline Predisposition in Pediatric Central Nervous System Tumors: Insights from a Multigene Panel Study.

Oncology research - 1 Jan 2026

Park Meerim, Park Seungman, Oh Ensel, Choi Jongmun, Kwon Mi Mi, Park Seog-Yun, Lee Jun Ah, Park Hyeon Jin

Abstract excerpt

Objectives: Germline variants in cancer predisposition genes have been increasingly recognized in pediatric cancers. However, their spectrum in East Asian children with central nervous system (CNS) tumors remains insufficiently defined. This study investigated the prevalence and clinical significance of pathogenic or likely pathogenic (P/LP) germline mutations in Korean children, adolescents, and young adults...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42232602
DOI: 10.32604/or.2026.079120
PMCID: PMC13223255

Genes

FANCI
BRIP1
FANCM
MLH1
MUTYH
NF1
PALB2
PMS2
SMARCB1
SUFU
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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