Germline genetic landscape of pediatric central nervous system tumors.

doi:10.1093/neuonc/noz108

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Article

Germline genetic landscape of pediatric central nervous system tumors.

Neuro-oncology - 4 Nov 2019

Muskens Ivo S, Zhang Chenan, de Smith Adam J, Biegel Jaclyn A, Walsh Kyle M, Wiemels Joseph L

Abstract excerpt

Central nervous system (CNS) tumors are the second most common type of cancer among children. Depending on histopathology, anatomic location, and genomic factors, specific subgroups of brain tumors have some of the highest cancer-related mortality rates or result in considerable lifelong morbidity. Pediatric CNS tumors often occur in patients with genetic predisposition, at times revealing underlying cancer...

Topics

Biomarkers, Tumor
Central Nervous System Neoplasms
Child
Genetic Predisposition to Disease
Genomics
Germ-Line Mutation
High-Throughput Nucleotide Sequencing
Humans

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Identifiers

PMID: 31247102
DOI: 10.1093/neuonc/noz108
PMCID: PMC6827836

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