Article

Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter.

1994-10-01

Abstract excerpt

The cell cycle-regulatory transcription factor E2F-1 is regulated by interactions with proteins such as the retinoblastoma gene product and by cell cycle-dependent alterations in E2F-1 mRNA abundance. To better understand this latter phenomenon, we have isolated the human E2F-1 promoter. The human E2F-1 promoter, fused to a luciferase cDNA, gave rise to cell cycle-dependent luciferase activity upon transfection in...

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Cancer-related Molecular Pathways

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Literature Corpus work: 1ad9fce0-c689-5193-9ca3-5ffcd4db4bde
DOI: 10.1128/mcb.14.10.6607

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