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Human Papillomavirus Type 16 E7 Binds to E2F1 and Activates E2F1-driven Transcription in a Retinoblastoma Protein-independent Manner

1 Jan 2002

Abstract excerpt

The human papillomavirus (HPV) E7 oncoprotein can immortalize primary human cells and induce tumor formation. These properties of E7 depend on its ability to inhibit the activity of retinoblastoma protein (pRB), which in turn affects E2F function. E2F proteins control the expression of genes involved in differentiation, development, cell proliferation, and apoptosis. By using genetic and biochemical approaches,...

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Cancer-related Molecular Pathways
Cervical Cancer and HPV Research
Viral-associated cancers and disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11713253
DOI: 10.1074/jbc.m109113200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Human Papillomavirus Type 16 E7 Binds to E2F1 and Activates E2F1-driven Transcription in a Retinoblastoma Protein-independent MannerPMID 11713253Read ↗

Human papillomavirus type 16 E7 oncoprotein associates with E2F6.Semantic proximity Read ↗

The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor proteinSemantic proximity Read ↗

Role of E2F in cell cycle control and cancerSemantic proximity Read ↗

Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600Semantic proximity Read ↗

High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve OncogenesisSemantic proximity Read ↗

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.Semantic proximity Read ↗

Evidence for direct interaction between the oncogenic proteins E6 and E7 of high-risk human papillomavirus (HPV)Semantic proximity Read ↗

Human Papillomavirus 16 Oncoprotein E7 Stimulates UBF1-Mediated rDNA Gene Transcription, Inhibiting a p53-Independent Activity of p14ARFSemantic proximity Read ↗

Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcriptionSemantic proximity Read ↗

Induction of pRb Degradation by the Human Papillomavirus Type 16 E7 Protein Is Essential To Efficiently Overcome p16 <sup>INK4a</sup> -Imposed G <sub>1</sub> Cell Cycle ArrestSemantic proximity Read ↗

Regulation of the retinoblastoma proteins by the human herpesvirusesSemantic proximity Read ↗

E2F-7 couples DNA damage-dependent transcription with the DNA repair process.Semantic proximity Read ↗

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