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Article

Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.

Science (New York, N.Y.) - 28 May 1993

Wang C Y, Petryniak B, Thompson C B, Kaelin W G, Leiden J M

Abstract excerpt

The retinoblastoma gene product (Rb) is a nuclear phosphoprotein that regulates cell cycle progression. Elf-1 is a lymphoid-specific Ets transcription factor that regulates inducible gene expression during T cell activation. In this report, it is demonstrated that Elf-1 contains a sequence motif that is highly related to the Rb binding sites of several viral oncoproteins and binds to the pocket region of Rb both...

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Identifiers

PMID: 8493578
DOI: 10.1126/science.8493578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.PMID 8493578Read ↗

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