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Article

Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity.

Molecular cell - 2 Jan 2020

Vivas-García Yurena, Falletta Paola, Liebing Jana, Louphrasitthiphol Pakavarin, Feng Yongmei, Chauhan Jagat, Scott David A, Glodde Nicole, Chocarro-Calvo Ana, Bonham Sarah, Osterman Andrei L, Fischer Roman, Ronai Ze'ev, García-Jiménez Custodia, Hölzel Michael, Goding Colin R

Abstract excerpt

Phenotypic and metabolic heterogeneity within tumors is a major barrier to effective cancer therapy. How metabolism is implicated in specific phenotypes and whether lineage-restricted mechanisms control key metabolic vulnerabilities remain poorly understood. In melanoma, downregulation of the lineage addiction oncogene microphthalmia-associated transcription factor (MITF) is a hallmark of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31733993
DOI: 10.1016/j.molcel.2019.10.014
PMCID: PMC7137507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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