Article

ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma

2023-11-01

Abstract excerpt

Cancer cellular heterogeneity and therapy resistance arise substantially from metabolic and transcriptional adaptations, but how these are interconnected is poorly understood. Here, we show that in melanoma, the cancer stem cell marker aldehyde dehydrogenase 1A3 (ALDH1A3) forms an enzymatic partnership with acetyl-CoA synthetase 2 (ACSS2) in the nucleus to couple high glucose metabolic flux with acetyl-histone H3...

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Literature Corpus work: 2d8f36d7-4de3-52a1-ab72-0c5cd420cfff
DOI: 10.1101/2023.10.28.564337

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