Article

FADS2-mediated fatty acid desaturation and cholesterol esterification are signatures of metabolic reprogramming during melanoma progression

2020-07-12

Abstract excerpt

Identifying metabolic alterations in disease progression has been challenged by difficulties in tracking metabolites at sub-cellular level. Here, by high-resolution stimulated Raman scattering and pump-probe imaging and spectral phasor analysis of melanoma cells grouped by MITF/AXL expression pattern and of human patient tissues paired by primary and metastatic status, we identify a metabolic switch from a pigment...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae325801-55a3-52e9-955e-e8a288ec4279
DOI: 10.1101/2020.07.12.198903

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FADS2-mediated fatty acid desaturation and cholesterol esterification are signatures of metabolic reprogramming during melanoma progressionDOI 10.1101/2020.07.12.198903Read

Secreted Apoe rewires melanoma cell state vulnerability to ferroptosisSemantic proximity Read

Melanoma Metabolism: Molecular Mechanisms and Therapeutic Implications in Cutaneous OncologySemantic proximity Read

Research advances in Raman imaging of single-cell phenotypes in fatty acid metabolism in cancers.Semantic proximity Read

Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity.Semantic proximity Read

Understanding Molecular Mechanisms of Phenotype Switching and Crosstalk with TME to Reveal New Vulnerabilities of Melanoma.Semantic proximity Read

Metabolic Reprogramming in Melanoma: An Epigenetic Point of ViewSemantic proximity Read

Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.Semantic proximity Read

Metabolic rewiring directs melanoma immunologySemantic proximity Read

Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulationSemantic proximity Read

Lipid droplets are a metabolic vulnerability in melanomaSemantic proximity Read

Genomic subtypes of cutaneous melanoma have distinct metabolic profiles: A single-cell transcriptomic analysis.Semantic proximity Read

Epigenetic reprogramming of melanoma cell state through fatty acid β-oxidation and Toll-like receptor 4 signalingSemantic proximity Read