Article

Lipid droplets are a metabolic vulnerability in melanoma

2022-05-05

Abstract excerpt

Melanoma exhibits numerous transcriptional cell states including neural crest-like cells as well as pigmented melanocytic cells. How these different cell states relate to distinct tumorigenic phenotypes remains unclear. Here, we use a zebrafish melanoma model to identify a transcriptional program linking the pigmented cell state to a dependence on lipid droplets, the specialized organelle responsible for lipid sto...

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Identifiers and source

Literature Corpus work: 8ae67454-ba07-5de4-aac4-0fe6f8812d9c
DOI: 10.1101/2022.05.04.490656

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