Article
Deep integrative models for large-scale human genomics.
Nucleic acids research - 7 Jul 2023
Sigurdsson Arnór I, Louloudis Ioannis, Banasik Karina, Westergaard David, Winther Ole, Lund Ole, Ostrowski Sisse Rye, Erikstrup Christian, Pedersen Ole Birger Vesterager, Nyegaard Mette, Brunak Søren, Vilhjálmsson Bjarni J, Rasmussen Simon
Abstract excerpt
Polygenic risk scores (PRSs) are expected to play a critical role in precision medicine. Currently, PRS predictors are generally based on linear models using summary statistics, and more recently individual-level data. However, these predictors mainly capture additive relationships and are limited in data modalities they can use. We developed a deep learning framework (EIR) for PRS prediction which includes a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.